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This upregulation of IGF-1 may potentially initiate a signaling cascade involving the activation of phosphoinositide 3-kinase (PI3K), an enzyme that may phosphorylate and activate protein kinase B (Akt)

Nuwaihyd R, Redler S, Heilmann S, Drichel D, Wolf S, Birch P, Dobson K, Lutz G, Giehl KA, Kruse R, Tazi-Ahnini R, Hanneken S, Bhm M, Miesel A, Fischer T, Wolff H, Becker T, Garcia-Bartels N, Blume-Peytavi U, Nthen MM, Messenger AG, Betz RC (2014) Investigation of four novel male androgenetic alopecia susceptibility loci: no association with female pattern hair loss

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