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Whole blood and plasma samples of six JVC rats were collected at 0.05, 0.167, 0.5, 1, 2, 4, 8, 24, 48, and 72 h after administration (three males and three females at each time point) for the examination of radio pharmacokinetics of total plasma

ACHIEVE-2: Up to 1.7% A1C reduction vs 0.8% with dapagliflozin (SGLT-2 inhibitor) ACHIEVE-5: Additional 2.1% A1C reduction when combined with insulin glargine Plus improvements in weight and cardiovascular risk factors Whats exciting is that this is a once-daily oral GLP-1 potentially expanding access to the same benefits seen with injectables like semaglutide

(PubMed) Cardoso BR, Braat S, Graham RM

TruTan supplies 10mg vials as standard, making dosing straightforward for both loading and maintenance phases