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Deichmann M, Thome M, Benner A, Egner U, Hartschuh W, Naher H

This was Citius second try for FDA approval, after the regulator rejected Lymphir in July 2023, outlining the need for enhanced product resting requirements. In its resubmitted data package, the company included findings from the from the Phase III Study 302 trial, where treatment with the drug led to an objective response rate of 36.2%, with 8.7% reaching complete response

Moreover, COX-2 inhibitors can cause metabolic imbalances that result in over production of two toxic cytokines, tumor necrosis factor alpha (TNF-) and interleukin 1 beta (IL-1) (Takahashi 1998

Ilango K, Chitra V