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The relationship between serum IGF-1, handgrip strength, physical performance and falls in elderly men and women
The effect was nominally significant for the GIPR/GLP-1R agonist (Beta: 0.35, 95%CI: 0.010.69, P = 0.046), while the associations for the GCGR/GLP-1R agonist (Beta: 0.28, 95%CI: 0.070.49, P = 7.97 10 3 ) and the GCGR/GIPR/GLP-1R agonist (Beta: 0.39, 95%CI: 0.110.66, P = 5.67 10 3 ) remained significant after multiple testing (Fig
Within laboratory research systems, mechanistic evaluation may include receptor-binding analysis, observation of intracellular signaling cascades, assessment of gene expression responses, and mapping of downstream regulatory pathways associated with IGF-mediated signaling under controlled in vitro conditions
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