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Protein oligomers of different pathogenic amyloidogenic proteins precede the fibril formation stage in HCCAA and other diseases, although for HCCAA, it is unclear if such oligomers lead directly to pathogenic fibrils or if assembly of fibrils occurs most rapidly from monomers 23
Variants in genes related to oxidative stress response (GSTM1, GSTT1, MnSOD, CYP2E1) show diverse associations with alcoholic liver disease across populations, making it difficult to generalize findings
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