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additionally, more research is required to investigate differences between NAD + modulators within different tissues, different models or pathologies, administration or exercise regimens, and how to successfully translate these findings to humans, while several clinical trials have already been conducted
Clin Nutr Res
Vitamin D signaling system genes, which has large CpG islands in their promoter regions and is prone to be regulated by DNA methylation and therefore can be silenced by de novo methylation 32,33,34,35
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