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After 6 months, metformin therapy for intervention group resulted in a significant decrease of FBG, HbA1c, total cholesterol, C-reactive protein (CRP), urinary albumin creatinine ratio (UACR) and CIMT while Nrg4 levels were increased compared with baseline levels (p 400 and/or presence of 2 atherosclerotic plaques in the carotid arteries) but without history of CVD or heart failure

Misuse, he said, raises the risk of side effects and inappropriate dosage, adding that regulators and companies must tighten prescription controls and promote awareness

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[PubMed: 18065800] 901