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Researchers believe this may be due to how GLP-1 affects the gut by: Slowing motility Modulating nerve signaling Possibly reducing visceral hypersensitivity (pain response) There is also some early evidence that GLP-1 medications may reduce overall IBS symptom severity and medication use, although more long-term data is needed 6

Patients who received liraglutide had slower reduction in MRI volume and cognition compared to placebo, the authors wrote in the poster abstract

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Activation of the glucagon receptor increases energy expenditure in the liver and adipose tissue, promoting fat bExperts forecast that retatrutide could substantially alter the obesity and diabetes treatment market