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Best candidates for retatrutide Retatrutide makes more sense for researchers who: Need maximum possible weight loss and have not achieved adequate results with dual agonists Have significant liver fat accumulation as a primary concern Have plateaued on tirzepatide or stopped responding Are comfortable with investigational compounds and research-grade sourcing Have higher side effect tolerance Want the most comprehensive metabolic intervention currently available Are experienced with GLP-1 agonist protocols and understand escalation management Have access to medical monitoring during the protocol Retatrutide is not a beginner compound

REDEFINE 3 evaluates cardiovascular outcomes (~7,000 participants, event-driven)

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doi: 10.3389/fendo.2019.00389 Received 07 April 2019 Accepted 30 May 2019 Published 19 June 2019 Volume 10 - 2019 Edited by Jens Juul Holst, University of Copenhagen, Denmark Reviewed by Leon Bach, Monash University, Australia