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Other calorie restriction interventions have noted increased alpha diversity (Shannon index) over short-term periods by implementing a high protein diet (30% of daily kcal) ( Differential abundance analysis revealed increases in several genera, including Incertae sedis and Eubacterium fissicatena group , and a decrease in Sellimonas in IF1-P

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The plan spent a projected $102 million on the drugs in 2023, or 10% of its roughly $1 billion in net pharmacy spending last year, The News & Observer previously reported

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