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43 Therefore, discontinuation of treatmentprimarily due to cost and access limitationsremains the major barrier to the widespread and sustainable use of these agents
Mounjaro (tirzepatide) EPAR Public Assessment Report
Acta Anaesthesiol Scand 68(5):584592 GRADEpro GDT: GRADEpro Guideline Development Tool [Software]
Cardiovascular Outcomes Liraglutide (LEADER trial): 13% reduction in major adverse cardiovascular events (MACE) in patients with Type 2 diabetes and high cardiovascular risk Statistically significant cardiovascular protection Semaglutide (SELECT trial): 20% reduction in MACE in patients with obesity and established cardiovascular disease Studied specifically for cardiovascular outcomes in obesity (not just diabetes) Both medications provide cardiovascular protection, but semaglutides evidence is more recent, more robust, and specifically applicable to patients with obesity regardless of diabetes status
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