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While nausea, vomiting, and diarrhea are the most commonly reported gastrointestinal adverse effects with GLP-1-based therapies (occurring in 15-40% of patients depending on the agent and dose), FDA prescribing information for several of these medications does list dyspepsia (indigestion) and, in some cases, gastroesophageal reflux disease (GERD) as reported adverse reactions
Why this approval matters: Helps reduce proteinuria: a key indicator of kidney damage
May reduce severity of depressive symptoms in the elderly
While these reports primarily involve compounded injectables rather than patches, they illustrate the dangers of unregulated products in the GLP-1 space
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