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[PubMed] [Google Scholar] 5.Lu SC

Of the 50 markers investigated, 4, 11 and 25 serum and plasma analytes were significantly different from controls in mild, moderate and severe groups, respectively after false discovery rate (FDR) correction and included several well-defined pro-inflammatory cytokines, including interferon- (IFN), interleukin-6 (IL-6), interleukin-1 (IL-1), interleukin-1RA (IL-1RA), interleukin-8 (IL-8) and 10 kDa interferon gamma-induced protein (IP-10)

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Although both conditions worsen before menstruation, PMDD is driven by brain sensitivity to hormonal shifts , while APD involves an immune reaction to progesterone