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The interpretation of these transcriptomic findings has been a continuing area of discussion, with some researchers viewing the broad effects as evidence of a regulatory function and others viewing them with caution given the difficulty of distinguishing direct effects from secondary consequences in such broad gene-expression landscapes

ART-nave patients showed altered haematological indices when compared with patients on ART and the seronegative controls

Long-term research will also guide clinical guidelines by clarifying maintenance strategies, cardiovascular outcomes, and optimal discontinuation protocols all of which affect value calculations for patients and payers