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As OTS964 treatment results not only in SF3B1 dephosphorylation, but also in stalling of spliceosome in B OTS964 intermediate, it is very likely that conformational change of the spliceosome itself also contributes to the observed decrease of P-SF3B1 binding to the ISL in U6 snRNA and we cannot distinguish between these two scenarios

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Therefore, there Currently, traditional cervical cancer screening methods, such as high-risk human papillomavirus testing and liquid based Brain tumors are among the most prevalent neoplasms in current medical studies

Multiple testing was addressed using false discovery rate (FDR) adjustment, and results were summarized with volcano plots generated in R