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In October 2023, the FDA designated CJC-1295 and Ipamorelin as Category 2 bulk drug substances effectively prohibiting them from being compounded by licensed pharmacies for human use

Gallbladder problems Gallbladder problems are an uncommon but serious side effect reported with Mounjaro which may be linked to rapid weight loss during treatment

Post-2020, indirect evidence from GHRH analog reviews (e.g., tesamorelin, which is FDA-approved for HIV lipodystrophy) suggests class effects, however, CJC-1295-specific trials are absent

Rare Complications Ozempic can rarely cause pancreatitis, severe hypoglycemia (especially when used with other glucose-lowering agents), gallbladder problems, acute kidney injury from dehydration, and allergic reactions