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Endocrinol Metab Clin N Am

Early research suggests transdermal GLP-1 delivery may provide consistent hormone levels, though clinical efficacy varies significantly based on individual biomarkers, baseline metabolic health, and adherence patterns

Interestingly, despite of the extracellular conformational differences induced by compound 2 and orthosteric agonists, their intracellular architectures underwent a similar reorganization of polar residues that enabled the formation TM6 sharp kink with the help of G protein binding 42,45 , indicative of GLP-1R activation (Fig