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Clinical studies show that moderate doses of semaglutide are effective for weight management at 3 and 6 months when combined with lifestyle modifications such as a healthy diet, meal tracking, portion control advice, psychosocial support, and physical activity coaching

As the model carries the common HFpEF co-morbidities (obesity, diabetes mellitus type 2, hypertension, kidney disease) and progresses over a long period (12 weeks), it is well suited to study the mechanisms of chronic HFpEF

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