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In addition, vitamin C might play a role in migraine headaches, but the efficacy of vitamin C supplementation in the prophylactic treatment of migraine has not been investigated in a randomized controlled trial

Treating mental health conditions Folate is involved in the production of brain chemicals called neurotransmitters

International Journal of Clinical and Experimental Medicine, 5 (3), 208.

In a double-blind randomized placebo-controlled study, a combination of acetaminophen (500 mg), acetylsalicylic acid (500 mg), and caffeine (130 mg) (AAC) was compared with ibuprofen (400 mg) and placebo for acute treatment of migraine