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These protective effects were absent in GLP-1R deficient (Glp1r^Wnt1/) mice, highlighting the critical role of neuronal GLP-1R signaling in mediating the anti-inflammatory and organ-protective actions of GLP-1RAs in sepsis ( Adiponectin, a highly abundant adipokine secreted by adipose tissue, plays a crucial role in regulating metabolism and inflammation due to its anti-diabetic, anti-inflammatory, and vasoprotective properties