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Phase I detoxification, i.e., P450 catalyzed monooxygenation of substrates resulting in the addition of one or more hydroxyl groups, converts insoluble organic compounds into hydrophilic ones, and facilitates their breakdown as well as the elimination of a wide variety of endogenous and exogenous compounds

Because this was a pre-post study without randomization or placebo control, the observed molecular shifts cannot be attributed unambiguously to L-serine

However, the specific mechanism has not been discussed yet, and there are still many obstacles in the clinical treatment of ferroptosis dependent on ncRNAs