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Risks of Extended GLP-1 Use The risks of extended GLP-1 use are still being studied, and while many people use them safely, potential concerns include: Digestive issues Some patients may experience ongoing nausea, constipation, or discomfort

Patients with a higher HbA1c during the pre-index period experienced greater HbA1c reductions

Semaglutide, a GLP-1 receptor agonist used for weight loss and diabetes, works on appetite control centers in the braina mechanism that can interact with opioid medications like oxycodone

Patients were followed for 3 years from the index event, defined as the time of PV diagnosis while receiving GLP-1a therapy