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FIGURE 6 In summary, GPX7 is an essential sensor for oxidative stress and endoplasmic reticulum stress ( 2.8 GPX8 Glutathione peroxidase 8 (GPX8) is a type II transmembrane protein with rare structural features that consists of 209 amino acids (Yoboue et al., 2017)

We developed liver-specific tet-on, TRE promoter-IRE (TG-IRE1) mice which have doxycycline (DOX)-induced increases in hepatic IRE1a and XBP1

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This disease-associated receptor signature, combined with growing evidence that microglial polarization can be shifted toward neuroprotective (M2-like) phenotypes, has opened exciting new avenues for targeted drug discovery