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Although the therapeutic benefits have yet to be reported for a specific GLP-1/antisense molecule designed to deliver a therapeutically-relevant antisense, the data suggest that GLP-1R is a suitable vector for in vivo tissue targeting, cellular internalization, and intracellular deposition of a cargo moiety

New England Journal Of Medicine *In a 68-week placebo-controlled study of 1,961 obese and overweight non-diabetic adults with weight-related conditions, those on semaglutide lost on average 14.9% of their weight as opposed to 2% of the placebo group

Its main mechanism of action is based on increasing the expression of BDNF (Brain-Derived Neurotrophic Factor) and its TrkB receptors in the hippocampus and prefrontal cortex, promoting synaptic plasticity, long-term potentiation (LTP), and memory consolidation (Dolotov et al., Neuroscience 2006)

The first part of the series will explore the historical beginnings of gentrification and how they still effect Denver and its residents today