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These results from both transcriptomic analysis and qRT-PCR indicated that the combination of (-)-Vestitol and Salviolone synergistically regulated the expression of the Glp1r , Htr4 , Ntsr1 , Nos1 , and Ntrk1 genes within the Neuroactive ligand-receptor interaction and Calcium signaling pathway

However, based on the Step 1 trial extension results, participants regained two-thirds of their prior weight loss after one year of withdrawal from weekly semaglutide injection and lifestyle interventions