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Microglia are resident immune cells of the CNS and are formed during early development and maintained throughout life, therefore maternal inflammation can lead to life-long impact on the individuals neuroinflammatory responses [77]

Coverage Considerations Saxenda: Longer FDA approval history (2014) may mean better coverage on some plans Step therapy: Some plans require trying Saxenda before approving Zepbound Zepbound: Superior efficacy (20.9% vs ~8% weight loss) may justify coverage even if more expensive Cash Pay Options If insurance doesn't cover your preferred option: Zepbound via LillyDirect: $299$449/month (vials, Dec 2025) Saxenda: ~$1,400/month retail

Carls GS, Tan R, Zhu JY, et al