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Maintenance dosing considerations: Community protocols commonly describe two maintenance approaches after the initial 8-12 week loading phase: (1) reduced frequency at the same dose (e.g., IV once monthly instead of weekly), or (2) transitioning from injectable/IV to high-bioavailability oral (liposomal) for convenience while accepting a modest reduction in peak levels

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These metabolic changes were accompanied by astrogliosis, including increased S100- and GFAP-positive astrocytic areas and higher ramification indices in the PTSD-like mice compared to the control (Fig

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