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This bypasses the skin barrier that limits topical absorption, allowing higher concentrations to reach the dermis and deeper tissue layers

Additionally, the expression of tight junction-associated proteins in colonic tissues was significantly upregulated after the intervention, suggesting that the intervention may attenuate damage to intercellular tight junctions triggered by inflammatory factors, thereby protecting the intestinal mucosal barrier integrity

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The treatment lasted 6 months, and the results obtained showed that in the subjects treated with ALA, the mean level of total GSH in the blood and CD4+ T-cell proliferation were signicantly elevated compared to the subjects taking the placebo