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New York, NY: Springer (2014)

Stay locked in on interval sessions and tempo work even when dieting has you feeling flat

Common gastrointestinal side effects include: Nausea (1222% of patients, dose-dependent) Diarrhea (1316% of patients) Vomiting (69% of patients) Constipation (67% of patients) Abdominal pain or discomfort (69% of patients) Decreased appetite (59% of patients) These effects are generally mild to moderate in severity and most pronounced during dose escalation

The mechanism is that MOTS-c increases the AMPK activity and enhances the insulin sensitivity of skeletal muscle cells, resulting in improved glucose metabolism [5]