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Individuals with conditions such as pernicious anemia, gastrointestinal disorders, or post-surgical digestive changes may lack sufficient intrinsic factor, making oral absorption inefficient

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A reasonable candidate is someone who: Is already following a structured, clinician-supervised nutrition and activity plan Has a documented B12 deficiency or a condition that impairs B12 absorption Cannot tolerate GLP-1 medications, or is not a candidate for them Declines prescription pharmacotherapy and wants a non-stimulant, non-surgical adjunct Understands because the clinician has said so plainly that the injection is a supporting player A poor candidate is someone who wants the shot instead of the program

Clinical Chemistry and Laboratory Medicine