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Regardless of the exact mechanism, people who have a mutation in the MTHFR gene and therefore defective forms of the MTHFR enzyme have been shown to have a higher prevalence of psychiatric disorders

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This is most relevant: During the first 4 weeks after initiating Wegovy For 4 weeks following each dose increase Non-oral contraceptive methods including IUDs, implants, patches, vaginal rings, and barrier methods are not affected by this interaction