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10.1016/j.neuroscience.2013.07.061 Neuroscience 45 TangG.YangG

Bao, H., He, X., Wang, F

Skipping it is the most common reason patients experience severe nausea early in treatment

Notably, most clinical investigations studied women (1404 female versus 83 male participants), which is expected since estrogen declines after age 30 years, and further estrogen decline with aging represents health challenges, as well as a reduction in QOL [9, 10, 19,20,21,22] and a degradation in the most visible organ of the bodythe skin [9, 10]