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Among the tested formulations, PNP-1-10-0.05 Sema-1.8 mg/mL exhibited the most favorable safety profile across all evaluated tissues, while PNP-1-10-0.05 TZP-4.5 mg/mL, though eliciting a modest increase in localized tissue response, remained substantially more biocompatible than daily bolus TZP

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2.4 Compartment-Specific GSH/GSSG Pools Glutathione pools differ across the cytosol, mitochondria, nucleus, endoplasmic reticulum, and extracellular space