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During disease progression, the accumulation of aberrant proteins can overwhelm the cellular chaperone system, as the demand for refolding and clearance exceeds its capacity 97

Aggregating data from Table 3 reveals consistent cross-barrier alterations in cytokine levels in both CSF and peripheral blood across different clinical stages (first-episode/FES, acute/ASZ, and chronic/CSZ), which hold clinical translational significance: 1)

Deficiency can lead to megaloblastic anemia and neurologic complications, while elevated levels may signal underlying liver disease or malignancy

The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation. Growth Hormone and IGF Research