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Alternative Mutations of a Positively Selected Residue Elicit Gain or Loss of Functionalities in Enzyme Evolution

L-carnitine may also prevent oxidative stress and cellular damage by acting as an antioxidant and scavenging free radicals

& Onoue, S

Additionally, HIF-1 modulates the pathogenesis and pathological processes of MS patients by regulating the hypoxic microenvironment, fibrosis, vascular dysfunction, immune inflammation, and skin calcification reactions (165, 173, 179)