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These effects are also seen in patients with T2DM and in other insulin-resistant states such as obesity [135, 136] and may be mediated in part by restoration of vascular insulin sensitivity [137]

A 2022 meta-analysis reviewed the statistical data of eight randomized controlled trials

Marketed as Ozempic, Wegovy, and Rybelsus, this transformative drug drives billions in revenue$14B for Ozempic in 2023 alonerevolutionizing type 2 diabetes mellitus (T2DM) and obesity management

Further studies on diverse ethnic samples are needed to confirm these findings and elucidate the genetic underpinnings of the T2DM-MDD relationship